Oncologists decide what kind of treatment to pursue with their patient. There are numerous options. There are no one size fits all treatment regimen for peritoneal mesothelioma sufferers. This is due to the cancers high mortality rate, rareness, low treatment success rate, and small number of studies to provide meaningful statistics.

While prospects for patients with mesothelioma have been bleak, doctors have been making progress. Traditional treatments for cancer are surgery (removing the tumor and surrounding tissue), chemotherapy (poisoning cancerous cells) and radiation (killing cancer cells with radiation) There are problems with all three. Traditional radiation therapy has not worked well with mesothelioma patients. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

Surgery takes out the mesothelial cancerous tissue around the tumor. This surgery is extensive and it is not clear how much the patient benefits. Most chemotherapy medication that work on other cancers typically do not work on mesothelioma, and different mixtures of these drugs have not been successful. Similar to radiation, focus in research is focusing on treating the physical location of the tumor with emphasis on the pleural cavity.

The high-mortality rate for mesothelioma patients means cutting-edge techniques for cancer are tried out. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. Pemetrexed (Alimta) is a new drug that has shown results in extending life.

Before acting, oncologists review the stage of mesothelioma, position of the tumor, and age and health status of the patient. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Mesothelioma patients sometimes become involved in clinical trials in this area, and see benefits.